Hi Brewer. First, what tx/rx are you using? Also might help if you list the motor, esc, prop. Did the motor get real hot when testing? Second, once you get the initial bind done, except in some very rare circumstances, would you have to bind again.
A twitching motor usually means a bad connection in the wires between the motor and esc, or even in the motor itself. Or it could mean a bad esc.
With all your re binding, I assume you made sure the throttle is at idle and throttle trim at neutral? Also, make sure the battery is fully charged. Maybe you're already on top of those but just throwing out ideas.