I have always done all the programming, esc setup with out a prop installed. Throttle calibration, motor directions, esc settings. Then I install the prop and stand BEHIND the plane. I hold smaller planes by hand, but always tie larger ones down. If I;m using a wattmeter, I secure the plane no matter the size. Never let anyone else stand in front or beside a plane either as its powered up! Never power up larger systems inside your house, take it outside where it belongs.
I'm sure we've all seen some of the pics of hand/arm damage done by propellers. Pretty gruesome for sure. Prop size is really irrelevent, even a little 5" prop spinning at 12000 rpm against your hide will inflict major/maybe even permanent damage.
It almost sounds like a rant, but my concern is for everyones safety.
Another tip to help save hides and equipment. If the ESC has a card/ programmer available, they are usually quite inexpensive and greatly enhance the safety and ease of setting up a new combo. The stick programming has caused more issues than it ever cured IMO. fly-barely